Effect of Genetic Variation in a Drosophila Model
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چکیده
4 0 The identification and validation of gene-gene interactions is a major challenge in 4 1 human studies. Here, we explore an approach for studying epistasis in humans using a 4 2 Drosophila melanogaster model of neonatal diabetes mellitus. Expression of the mutant 4 3 preproinsulin (hINS C96Y) in the eye imaginal disc mimics the human disease: it activates 4 4 conserved stress response pathways and leads to cell death (reduction in eye area).
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تاریخ انتشار 2013